Circumcision and Factor XI (eleven) deficiency , also known as Haemophilia C.
Factor XI (eleven) deficiency (also known as Haemophilia C) is a bleeding disorder which can affect all people of all heritages it is common in Ashkenazi Jewish people. Most cases of factor XI deficiency are inherited and caused by changes (mutations) in the F11 gene The genetic Inheritance is autosomal recessive (common) or dominant (rare). It affects males and females equally. Bleeding can occur after surgical operations including circumcision Bris Milah but there are a number of treatments which can be given to prevent bleeding.
Dr Martin Harris worked with Dr. Niamh O’Connell when she investigated aspects of factor XI deficiency and developed a protocol for the management of circumcision on the male infants of factor XI deficient patients. Dr O’Connell was then working as a research fellow at the Haemophilia Centre and Haemostasis Unit Royal Free Hospital in London with Professor Christine Lee. Dr Harris works with Dr Ri Liesner, Consultant Haematologist & Director of the Haemophilia Centre Great Ormond Street Hospital for Children London.